Cardiac Spiral Wave Termination by Linear Regional Cooling Toward the Anatomical Boundary of the Heart

Autor: Masatoshi Yamazaki, Haruo Honjo, Naoki Tomii, Nitaro Shibata, Ichiro Sakuma, Hiroshi Seno
Rok vydání: 2020
Předmět:
Zdroj: Journal of Medical and Biological Engineering. 40:400-408
ISSN: 2199-4757
1609-0985
DOI: 10.1007/s40846-020-00517-8
Popis: Purpose We hypothesized that linear regional cooling (LRC) toward the atrio-ventricular groove (AV-G) can move the spiral wave (SW) center to the AV-G effectively and terminate SW. The effectiveness of LRC in ex vivo 2D ventricle rabbit experiments was tested. Methods We developed an experimental system to operate LRC and optical mapping simultaneously. To realize simultaneous cooling and optical mapping, a transparent cooling device was developed. LRC for 60 s toward 2D subepicardial ventricular myocardium of Langendorff-perfused rabbit hearts (n = 4) was conducted during constant pacing and persistent ventricular tachyarrhythmias (VTs). Results Action potential duration at 90% repolarization (APD90) at the cooling area was prolonged by LRC from 187 to 228 ms. 41% of persistent VTs were terminated by LRC (12/29 cases). Cases where the original SW center moved toward the AV-G were observed via optical mapping. However, there were some cases where VT was not terminated by LRC. When the action potential duration (APD) of VT sustained cases were analyzed, LRC prolonged APD, but the APD prolonged area did not move toward the AV-G in most VT sustained cases Conclusion Proper LRC toward the AV-G near the original SW center could move this center toward the AV-G and terminate SW excitation.
Databáze: OpenAIRE
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