Induction of HA-1-specific cytotoxic T-cell clones parallels the therapeutic effect of donor lymphocyte infusion
| Autor: | Günther Gastl, David Nachbaur, Kurt Grünewald, Martina Urbanek, Stefan Stevanovic, Andrea Mitterschiffthaler, Brigitte Kircher, Hans-Georg Rammensee |
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| Rok vydání: | 2002 |
| Předmět: |
business.industry
Lymphocyte Hematology medicine.disease Donor lymphocyte infusion Transplantation surgical procedures operative medicine.anatomical_structure Graft-versus-host disease immune system diseases hemic and lymphatic diseases Acute lymphocytic leukemia Immunology Minor histocompatibility antigen medicine Cytotoxic T cell business CD8 |
| Zdroj: | British Journal of Haematology. 117:935-939 |
| ISSN: | 0007-1048 |
| DOI: | 10.1046/j.1365-2141.2002.03536.x |
| Popis: | Summary. Donor lymphocyte infusions (DLI) can induce a graft-versus-leukaemia (GvL) reaction in patients with relapsed disease. However, the mechanisms involved in remission induction are not completely known. A patient with chemotherapy-refractory relapse 1 year after human leucocyte antigen (HLA)-identical, unrelated stem cell transplantation (SCT) for bcr/abl-positive common acute lymphoblastic leukaemia (ALL) received a DLI from the original donor, and achieved complete cytogenetic and molecular remission concomitantly with extensive graft-versus-host disease (GvHD). Seven CD8+, donor-derived, alloreactive T-cell clones were generated by stimulating post-DLI remission cells with the patient's pretransplant mature dendritic cells. The minor histocompatibility antigen (mHag) recognized by these T-cell clones was identified as HA-1, a mHag associated with acute GvHD after SCT. Our finding provides evidence of HA-1-associated GvL effects after DLI that paralleled the eradication of full-blown, chemotherapy-refractory ALL relapse after allogeneic SCT. |
| Databáze: | OpenAIRE |
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