Potential Biomarkers of Posttraumatic Stress Disorder
| Autor: | M. V. Dorofeikova, N. N. Petrova, B. G. Butoma |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
business.industry
Biochemical biomarkers medicine.disease Mental illness behavioral disciplines and activities Comorbidity Psychiatry and Mental health Clinical Psychology Posttraumatic stress Risk groups Neuroimaging medicine Anxiety medicine.symptom business Biological Psychiatry Depression (differential diagnoses) Clinical psychology |
| Zdroj: | Psikhiatriya. 19:90-99 |
| ISSN: | 2618-6667 1683-8319 |
| DOI: | 10.30629/2618-6667-2021-19-3-90-99 |
| Popis: | Background: although the search for biomarkers of mental disorders that is aimed at improving diagnosis, individualizing therapy based on knowledge of pathophysiological processes and preventing the development of mental illness is actively underway for endogenous mental disorders, the study of biological markers in non-endogenous mental disorders and posttraumatic stress disorder (PTSD) in particular has received much less attention.Aim: to analyze current state of research dedicated to genetic and biochemical biomarkers that can be used to identify high risk groups and clarify the diagnosis of PTSD.Material and method: keywords “biomarkers”, “post-traumatic stress disorder”, “pathogenesis” have been used to fi nd in PubMed articles published in 2010–2020.Conclusion: research methods for elucidating the mechanisms of PTSD are actively developing, however, the identifi cation of specifi c biomarkers (biochemical, molecular, genetic, epigenetic, neuroimaging, psychophysiological) is a complicated task. This complexity is associated with numerous pathogenic mechanisms of PTSD and frequent comorbidity with mental disorders (depression, anxiety) and somatic diseases, as well as lack of specifi city of detected biomarkers. |
| Databáze: | OpenAIRE |
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