| Autor: |
Evgeniy Martynenko, Tamara Obydennikova, Kirill Stegniy, Ivan Reva, Marina Fleischman, Aleksandr Zolotov, Dmitriy Zvyagintsev, Sergey Terekhov, Olga Lebedko, Igor Sementsov, Ellada Slabenko, Galina Reva, Viktor Usov |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Archiv Euromedica. 12:65-68 |
| ISSN: |
2199-885X |
| Popis: |
With the permission of the Ethics Committee of the Far Eastern Federal University and in accordance with Russian legislation and the Declaration of Helsinki (2013), immunohistochemical studies were carried out and morphological criteria were developed for the readiness of burn wounds for autodermoplasty with predicted efficacy. The aim of the study was to optimize active surgical tactics in the treatment of burns with the development of morphological criteria for determining the timing of effective autodermotransplantation. The analysis of the material in 4 groups of patients was carried out: group 1 with autodermotransplantation in the first 7 days (32 patients); 2nd group — after 7 to 14 days (24) and after 14 days due to the insufficient number of Lonor sites (4), as well as with the final covering of wounds even at a later date due to rejection and microbial contamination in the wound after 21 days (2 patients). It was found that the optimal time for complete covering of burn wounds is 7–8 days after thermal injury. On the 9–14th day, the conditions for autodermoplasty are preserved, but in the wounds the phenomena of scar tissue formation and vascular hardening occur. In terms later than 14 days after the injury, the conditions for autodermoplasty worsen, the effectiveness of treatment decreases and is accompanied by the healing of the tissue defect with scarring. Autodermoplasty after 2 weeks is accompanied by a decrease in reparative processes with the induction of pathological angiogenesis, an aggressive reaction of immunocompetent cells with non-infectious destruction and lysis of the graft, which requires significant correction of therapeutic measures. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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