High infiltration of CD20 + B lymphocytes in extranodal natural killer/T‐cell lymphoma is associated with better prognosis
| Autor: | Min‐Min Chen, Guo‐Peng Zeng, Jing Li, Jun‐Hong Fu, Ya‐Yi Long, Jie‐Ying Pan, Lin‐Zhi Wei, Jie‐Ying Guan, Ying‐Xi Lin, Hua You, Cheng Si, Wen‐Xing Li, Yi‐Jun Liang, Da‐Hai Liu, Fang Liu |
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| Rok vydání: | 2020 |
| Předmět: |
CD20
biology business.industry Hematology medicine.disease Natural killer T cell Phenotype Lymphoma 03 medical and health sciences 0302 clinical medicine Immune system 030220 oncology & carcinogenesis medicine Cancer research biology.protein Immunohistochemistry Clinical significance business Infiltration (medical) 030215 immunology |
| Zdroj: | British Journal of Haematology. 191 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/bjh.17069 |
| Popis: | Immune cells have an uncertain function during the progression of extranodal natural killer/T-cell lymphoma (ENKTL). The present study determined the distribution, phenotype, and clinical significance of B lymphocytes in ENKTL. Immunohistochemistry indicated high infiltration of CD20+ B lymphocytes in the tumour tissues of 40% of the patients, and that a high infiltration correlated with better overall survival. Moreover, B lymphocytes had an active mature phenotype in situ and suppressed the proliferation of ENKTL cells in vitro. These results suggest that tumour infiltration of CD20+ B lymphocytes may be a new prognostic indicator for patients with ENKTL. |
| Databáze: | OpenAIRE |
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