Mechanisms of action of the mood stabilizer valproate: a focus on GSK-3 inhibition

Autor:	Julia F Ishak, Miriam L. Greenberg, Abed N. Azab, Vered Delbar, Jacob Kaplanski
Rok vydání:	2008
Předmět:	Valproic Acid Lithium (medication) medicine.drug_class Mood stabilizer Biology Pharmacology medicine.disease Neurology Mechanism of action Migraine GSK-3 medicine Neurology (clinical) Bipolar disorder Histone deacetylase medicine.symptom medicine.drug
Zdroj:	Future Neurology. 3:433-445
ISSN:	1748-6971 1479-6708
DOI:	10.2217/14796708.3.4.433
Popis:	Valproate is the most widely prescribed antiepileptic drug worldwide, and it is also used in the treatment of bipolar affective disorder, migraine headache and cancer. However, the therapeutic mechanism of action of valproate in these illness states is not understood. This article reviews the pharmacological effects of valproate that may explain its therapeutic efficacy. It focuses on the hypothesis that inhibition of glycogen synthase kinase-3 by valproate is a crucial therapeutic mechanism of this drug in the treatment of bipolar affective disorder. Other cellular pathways and signaling molecules that are targets of valproate (such as inositol de novo biosynthesis, histone deacetylase, protein kinase C, γ-aminobutyric acid, the extracellular signal-regulated kinase pathway and others) are also discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5db05af5e91799d5c986bff23dc18702 https://doi.org/10.2217/14796708.3.4.433 Zobrazit plný text záznamu