| Autor: |
Wei Li, Hai-Bin Chen, Zhan Yang, Kai-Long Liu, Bao-Sai Lu, Zi-Yi Wang |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Current Molecular Medicine. 23 |
| ISSN: |
1566-5240 |
| DOI: |
10.2174/1566524023666230529143837 |
| Popis: |
Background: The c-ETS-1 (ETS1) expression is high in clear cell renal cell carcinoma (ccRCC) tissues; however, how it impacts ccRCC is currently unknown. Method: The online STRING web source was used to construct a protein network interacting with ETS1. The Cell Counting Kit-8 was used to detect the cell viability. A clonogenic assay, a wound-healing assay, and a Transwell assay were used to detect cell proliferation, invasion and migration abilities. Western blot was used to detect the expression of proteins. Result: The data showed the expression of ETS1 in ccRCC tissues to be significantly increased compared to adjacent tissues (p Conclusion: A high expression of ETS1 is associated with the progression of ccRCC. This study suggests that ETS1 promotes proliferation by increasing MMP2 expression in ccRCC, and combined knockdown of ETS1 and inhibition of ERK can significantly inhibit the proliferation, migration and invasion of ccRCC. ETS1 may be a therapeutic and prognostic target for renal cell carcinoma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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