Study of the distribution and kinetics of [14C]sarcolysine in rats

Autor: Reztsova Vv, Filov Va, Kil'maeva Ne, N. K. Kharina, T. A. Mironyuk, V. V. Korsakov, S. A. Kon'kov
Rok vydání: 1992
Předmět:
Zdroj: Pharmaceutical Chemistry Journal. 26:30-33
ISSN: 1573-9031
0091-150X
Popis: One of the first antitumor drugs sarcolysine [4-bis(2-chloroethyl)-aminophenylalanine, mixture of isomers] and its L-isomer, melfalan, have been widely used clinically up to this time [i, 8, i0]. A number of researchers have used various methods to study the pharmacokinetics of the drug in rats [7], mice [5], rabbits [ii], dogs [6], monkeys [3], and human [2, 4, 9], chiefly its elimination from the blood. The aim of this investigation was to study the complex of kinetic parameters of sarcolysine in rats in the case of various modes of administration and doses.
Databáze: OpenAIRE
Externí odkaz: