Dispersion of repolarization and beta-thalassemia major: the prognostic role of QT and JT dispersion for identifying the high-risk patients for sudden death
| Autor: | Maria Giovanna Russo, Paolo Golino, Federica Di Meo, Bruno Pannone, Anna Spasiano, Gerardo Nigro, Maria Carolina Mayer, Raffaele Calabrò, Anna Rago, Andrea Antonio Papa, Vincenzo Russo |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities medicine.medical_specialty education.field_of_study business.industry Population Hematology General Medicine medicine.disease QT interval Sudden death Sudden cardiac death Internal medicine Cardiology medicine Repolarization Cutoff Statistical dispersion cardiovascular diseases education business Body mass index |
| Zdroj: | European Journal of Haematology. 86:324-331 |
| ISSN: | 0902-4441 |
| DOI: | 10.1111/j.1600-0609.2011.01579.x |
| Popis: | Background: Patients with beta-thalassemia major (β-TM) are at increased risk for sudden cardiac death (SCD). Heterogeneity of ventricular repolarization is considered to provide an electrophysiological substrate for malignant arrhythmias. QT dispersion (QTc-D) and JT dispersion (JTc-D) are electrocardiographic parameters indicative of heterogeneity of ventricular repolarization. The aim of our study was to evaluate the heterogeneity of ventricular repolarization in patients with beta-thalassemia and to test the hypothesis that an abnormal QTc and JTc dispersion may predict SCD in this population. Materials and Methods: The study involved 51 patients with β-TM (age 33.9 ± 8.4; 33 M) and 51 healthy subjects used as controls, matched for age, gender, and body mass index (BMI). Among the β-TM group, 14 patients with β-TM (age 27 ± 6.64; 11 M) died from SCD during follow-up. For each patient, QTD and JTD intervals were calculated. Results: Compared to the healthy control group, β-TM group presented increased values of the QTc-D (65.36 ± 33.95 vs. 37, 62 ± 17.65; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|