Protective effects of taurine on human hair follicle grown in vitro1
| Autor: | P. Hallegot, Philippe Bastien, Sandrine Chabane, Francis Pruche, M. Peyron, C. Collin, Sebastien Thibaut, M. Bouleau, B.A. Bernard, Brigitte Gautier, Olivier Gaillard, Albert Duranton |
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| Rok vydání: | 2006 |
| Předmět: |
Aging
medicine.medical_specialty Taurine Methionine integumentary system Pharmaceutical Science Connective tissue Dermatology Biology Outer root sheath Hair follicle chemistry.chemical_compound Follicle Colloid and Surface Chemistry medicine.anatomical_structure Endocrinology chemistry Chemistry (miscellaneous) In vivo Internal medicine Drug Discovery otorhinolaryngologic diseases medicine sense organs Transforming growth factor |
| Zdroj: | International Journal of Cosmetic Science. 28:289-298 |
| ISSN: | 1468-2494 0142-5463 |
| Popis: | Taurine is a naturally occurring beta-amino acid produced by methionine and cysteine metabolism. It is involved in a variety of physiological functions, including immunomodulatory and antifibrotic. Taking advantage of the ability of human hair follicle grown in vitro to recapitulate most of the characteristic features of normal hair follicle in vivo, we studied (i) taurine uptake by isolated human hair follicles; (ii) its effects on hair growth and survival rate; and (iii) its protective potential against transforming growth factor (TGF)-beta1, an inhibitor of in vitro hair growth and a master switch of fibrotic program. We showed that taurine was taken up by the connective tissue sheath, proximal outer root sheath and hair bulb, promoted hair survival in vitro and prevented TGF-beta1-induced deleterious effects on hair follicle. |
| Databáze: | OpenAIRE |
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