Verbal memory impairment in subcortical ischemic vascular disease

Autor:	Michael O'Sullivan, Anand Viswanathan, Eric Jouvent, K. Hernandez, Sonia Reyes, Martin Dichgans, Stéphane Epelbaum, M.G. Bousser, A. Kurtz, Hugues Chabriat, D. Hervé, Sarah Benisty, Christian Opherk, Marco Düring
Rok vydání:	2011
Předmět:	Aging medicine.medical_specialty Recall General Neuroscience Neuropathology Audiology medicine.disease medicine Dementia Memory impairment Neurology (clinical) Geriatrics and Gerontology Verbal memory Vascular dementia CADASIL Psychology Neuroscience Episodic memory Developmental Biology
Zdroj:	Neurobiology of Aging. 32:2172-2182
ISSN:	0197-4580
Popis:	In the elderly, the high prevalence of Alzheimer's disease neuropathology presents a major challenge to the investigation of memory decline in common diseases such as small vessel disease. CADASIL represents a unique clinical model to determine the spectrum of memory impairment in subcortical ischemic vascular dementia (SIVD). One hundred and forty CADASIL patients underwent detailed clinical, neuropsychological and imaging analyses. The Free and Cued Selective Reminding Test was used as a measure of verbal memory. Forty-four out of 140 CADASIL patients (31.4%) presented with memory impairment according to this test. Eight out of 44 (18.2%) subjects with memory impairment matched the definition of the amnestic syndrome of hippocampal type. While alterations in spontaneous recall were related to the severity of subcortical ischemic lesions, the profile of memory impairment, particularly the sensitivity to cueing was found related to other factors such as hippocampal atrophy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5d8a279bdfd6c5d267db4b51d10b7050 https://doi.org/10.1016/j.neurobiolaging.2009.12.018 Zobrazit plný text záznamu Full Text from ScienceDirect