Effect of combined supplementation with vitamin E and alpha-lipoic acid on myocardial performance duringin vivo ischaemia-reperfusion

Autor: Karyn L. Hamilton, Li Li Ji, Jeff S. Coombes, R. A. Shanely, Heather K. Vincent, Hisashi Naito, J. Jessup, Scott K. Powers, Lester Packer, Chandan K. Sen, Haydar A. Demirel
Rok vydání: 2000
Předmět:
Zdroj: Acta Physiologica Scandinavica. 169:261-269
ISSN: 0001-6772
Popis: Reactive oxygen species (ROS) contribute significantly to myocardial ischaemia-reperfusion (I-R) injury. Recently the combination of the antioxidants vitamin E (VE) and alpha-lipoic acid (alpha-LA) has been reported to improve cardiac performance and reduce myocardial lipid peroxidation during in vitro I-R. The purpose of these experiments was to investigate the effects of VE and alpha-LA supplementation on cardiac performance, incidence of dysrhythmias and biochemical alterations during an in vivo myocardial I-R insult. Female Sprague-Dawley rats (4-months old) were assigned to one of the two dietary treatments: (1) control diet (CON) or (2) VE and alpha-LA supplementation (ANTIOXID). The CON diet was prepared to meet AIN-93M standards, which contains 75 IU VE kg-1 diet. The ANTIOXID diet contained 10 000 IU VE kg(-1) diet and 1.65 g alpha-LA kg(-1) diet. After the 14-week feeding period, significant differences (P 0.05) existed in cardiac performance (e.g. peak arterial pressure or ventricular work) or the incidence of ventricular dysrhythmias during the I-R protocol. Following I-R, two markers of lipid peroxidation were lower (P
Databáze: OpenAIRE
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