Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme

Autor:	Hoyer Denton W, Schmidt Stanley J, Roland E. Dolle, C. V. C. Prasad, I. Kelly Osifo, Mark A. Ator, Carla T. Helaszek, Prouty Catherine P, Mohamad M. A. Awad, Tina Morgan Ross, Robert E. Miller, Salvino Joseph M, Todd L. Graybill
Rok vydání:	1995
Předmět:	chemistry.chemical_classification Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Substrate (chemistry) Biochemistry Amino acid Enzyme chemistry mental disorders Drug Discovery Molecular Medicine Interleukin 1β converting enzyme Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:315-318
ISSN:	0960-894X
DOI:	10.1016/0960-894x(95)00027-q
Popis:	Structural and stereochemical requirements of substrate based time-dependent inactivators of interleukin-1β converting enzyme were investigated. Hydrophobic amino acids with L-stereochemistry are preferred at the P 2 and P 3 positions. It appears that both D-and L-Asp are accepted by the enzyme at the P I position.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5d860e9840b28bfc343aeab74eba9474 https://doi.org/10.1016/0960-894x(95)00027-q Zobrazit plný text záznamu Full Text from ScienceDirect