Insights into targeting SARS-CoV-2: design, synthesis, in silico studies and antiviral evaluation of new dimethylxanthine derivatives
| Autor: | Abdalla R. Mohamed, Ahmed Mostafa, Mahmoud A. El Hassab, Gomaa M. Hedeab, Sara H. Mahmoud, Riham F. George, Hanan H. Georgey, Nagwa M. Abdel Gawad, Mohamed K. El-Ashrey |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | RSC Medicinal Chemistry. 14:899-920 |
| ISSN: | 2632-8682 |
| Popis: | The expanded structure- and ligand-based drug design strategy was utilized to obtain a multitargeting SARS-CoV-2 inhibitor, compound 9a, with an IC50 value of 8.86 μM. |
| Databáze: | OpenAIRE |
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