Observed progression from melanosis with melanocyte hyperplasia to sinonasal melanoma with distant metastasis and a unique genetic rearrangement
| Autor: | Behzad Salari, Lyn M. Duncan, Kevin S. Emerick, Jochen K. Lennerz, Eric H. Holbrook, Ruth K. Foreman |
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| Rok vydání: | 2021 |
| Předmět: |
Allergy
Pathology medicine.medical_specialty Histology business.industry Macular hyperpigmentation Mucosal melanoma Dermatology Melanocyte Hyperplasia medicine.disease Pathology and Forensic Medicine Metastasis Melanosis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis medicine business Rare disease |
| Zdroj: | Journal of Cutaneous Pathology. 48:948-953 |
| ISSN: | 1600-0560 0303-6987 |
| Popis: | Melanosis, clinically presenting as a benign macular hyperpigmentation, consists of increased pigmentation (melanotic or melanocytic) either in the mucosal epithelial cells or as subepithelial pigment-laden macrophages. On the other hand, primary sinonasal mucosal melanoma (SNMM) is a rare disease with poor prognosis and high rates of local recurrence and metastasis. We report follow-up on a previously presented case of a 53-year-old man with recurrent clinical melanosis that progressed from histopathological melanocytic hyperplasia to melanoma in situ over a period of 4.8 years (Yao et al. Allergy Rhinol (Providence), 2016;7(3):164-167). The patient experienced multiple recurrences and local spread despite multiple extensive surgeries. We now report that this patient ultimately developed bilateral invasive SNMM and died with metastatic melanoma. Molecular analysis of the invasive melanoma revealed ALK rearrangement, specifically an EML4-ALK fusion, which represents the first report of this particular genetic variant in mucosal melanoma. |
| Databáze: | OpenAIRE |
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