Development of approaches to fibrostatin F, N-acetyl-L-cysteinyl-containing 1,4-naphthoquinone metabolite of Streptomyces catenulae

Autor:	Vladimir A. Denisenko, Yu. E. Sabutskii, Pavel S. Dmitrenok, Sergey G. Polonik
Rok vydání:	2016
Předmět:	010405 organic chemistry Stereochemistry Metabolite General Chemistry 1 4-Naphthoquinone 01 natural sciences 0104 chemical sciences Streptomyces catenulae 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Paraformaldehyde Microbial metabolite N-acetyl-L-cysteine
Zdroj:	Russian Chemical Bulletin. 65:774-778
ISSN:	1573-9171 1066-5285
Popis:	A possibility of the synthesis of microbial metabolite Streptomyces catenulae fibrostatin F through the AcOH-catalyzed condensation of 5-hydroxy-3-hydroxymethyl-2,7-dimethoxy1,4-naphthoquinone and its related 3-chloromethyl, 3-acetoxymethyl, and 3-methoxymethyl derivatives with N-acetyl-L-cysteine and paraformaldehyde in 1,4-dioxane was studied. In these conditions, all naphthoquinones gave N-acetyl-S-[(8-hydroxy-3,6-dimethoxy-1,4-dioxonaphthalen-2-yl)methyl]-L-cysteine isomeric to the natural fibrostatin C.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5d6c2d8ae1ce88f294e883ea3769a3bf https://doi.org/10.1007/s11172-016-1372-5 Zobrazit plný text záznamu Full text from SpringerLink