| Popis: |
Variable responses among individual patients, in addition to adverse effects are the main challenges facing most commonly used antiplatelet therapies like aspirin for example. Therefore, there is a need to seek naturally occurring, plant-derived substances which show minimal side effects. Capparis decidua is an indigenous shrub widely distributed in desert and semi-desert area of northern and central Sudan. Phytochemical investigation of aerial parts of Capparis decidua resulted in isolation of two new sesquiterpine lactones: MW-6 ( germacr-3βol-7,9-dien-6,14-olide-15-oic acid) and MW-11 (Germacr-3β-ol-12-ene-6,14-olide-15-oic acid) along with several known compounds. The two compounds have shown potent antiplatelets activity evaluated by using of guinea-pig platelets rich plasma mode. These compounds may provide a chemical moiety for more potent analogues. |
