Ni-Doped ZrO2 nanoparticles decorated MW-CNT nanocomposite for the highly sensitive electrochemical detection of 5-amino salicylic acid
| Autor: | Bih-Show Lou, Siva Kumar Krishnan, Tse-Wei Chen, Shen-Ming Chen, Nandini Nataraj |
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| Rok vydání: | 2021 |
| Předmět: |
Detection limit
Nanocomposite Materials science 02 engineering and technology Carbon nanotube Glassy carbon 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry law.invention law Electrode Electrochemistry Environmental Chemistry Differential pulse voltammetry Cyclic voltammetry 0210 nano-technology Biosensor Spectroscopy Nuclear chemistry |
| Zdroj: | The Analyst. 146:664-673 |
| ISSN: | 1364-5528 0003-2654 |
| DOI: | 10.1039/d0an01507e |
| Popis: | In this work, Ni-doped ZrO2 nanoparticles (NPs) were used to decorate multi-walled carbon nanotubes (MWCNTs) to obtain a Ni-ZrO2/MWCNT nanocomposite, which acted as an efficient electrode material for the highly sensitive electrochemical detection of the anti-inflammatory drug 5-amino salicylic acid (5-ASA). The Ni-ZrO2 NPs were obtained through a facile co-precipitation method, and the subsequent support of these Ni-ZrO2 NPs onto MWCNTs was accomplished via an ultrasonication technique. Supporting Ni-ZrO2 NPs on MWCNTs not only results in excellent catalytic properties, but it also substantially enhances the surface area, electrical conductivity, and electron transfer process. The electrochemical activity of the synthesized Ni-ZrO2/MWCNT nanocomposite was systematically investigated via cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The constructed Ni-ZrO2/MWCNT-modified glassy carbon (GC) electrode manifests superior electrocatalytic oxidation activity toward 5-ASA, with a lower peak potential compared with Ni-ZrO2-NP- and MWCNT-modified GC electrodes. Importantly, the proposed biosensor exhibited excellent sensitivity during the detection of 5-ASA with a wide linear concentration range (0.001-500 μM) and a low detection limit of 0.0029 μM. Moreover, the biosensor demonstrated excellent repeatability, reproducibility, stability, and high specificity toward 5-ASA detection in the presence of different interfering species. Furthermore, the biosensor showed satisfactory recovery rates in complex biological samples, such as human blood serum, human urine, and 5-ASA tablet samples. |
| Databáze: | OpenAIRE |
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