Investigation of Nanodrug Phospholipovit by Small-Angle Neutron Scattering

Autor:	A. I. Ivankov, Mikhail A. Kiselev, V. L. Aksenov, I. V. Gapon, Mikhail V. Avdeev, D. N. Selyakov, O. M. Ipatova
Rok vydání:	2019
Předmět:	010302 applied physics Materials science Aqueous solution Scattering Vesicle Analytical chemistry General Chemistry Radius Neutron scattering 010403 inorganic & nuclear chemistry Condensed Matter Physics 01 natural sciences Small-angle neutron scattering 0104 chemical sciences 0103 physical sciences General Materials Science Neutron reflectometry Lipid bilayer
Zdroj:	Crystallography Reports. 64:656-661
ISSN:	1562-689X 1063-7745
Popis:	The structure of aqueous solutions of the Phospholipovit medicine, intended for transport of water-insoluble molecular drugs, has been investigated by small-angle neutron scattering. Phospholipovit can also be used alone, for example, in case of acute poisoning. When processing experimental data, neutron reflectometry was additionally applied to determine the scattering characteristics of maltose buffer solutions in which the medicine is stored. It is shown that Phospholipovit forms temperature-resistant (in the range of 20–37°C) vesicles of critically small size, with inner radius (~40 A) comparable with lipid bilayer thickness (~31 A), in these solutions. The sensitivity of vesicle parameters to an increase in the medicine concentration in solution (up to 25 wt %) and the character of vesicle interaction (indicating the presence of a significant charge on their outer surface) are determined.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5d5b53631ead7c99c1d8459b7554354f https://doi.org/10.1134/s1063774519040114 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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