Redistribution of Sarcomeric Myosin and α-Actinin in Cardiomyocytes in Culture upon the Rearrangement of their Contractile Apparatus

Autor:	N. B. Bildyug, S. Yu. Khaitlina
Rok vydání:	2019
Předmět:	0301 basic medicine Gene isoform 030102 biochemistry & molecular biology macromolecular substances Cell Biology Biology Contractile apparatus Cell biology 03 medical and health sciences 030104 developmental biology Smooth muscle Cytoplasm α actinin Sarcomeric myosin Myofibril Actin
Zdroj:	Cell and Tissue Biology. 13:360-365
ISSN:	1990-5203 1990-519X
DOI:	10.1134/s1990519x1905002x
Popis:	Cardiomyocytes in culture undergo reversible rearrangement of their contractile apparatus with conversion of typical myofibrils into structures resembling stress fibers of nonmuscle cells. Such rearrangement is accompanied by the replacement of cardiac actin, the main protein of myofibrils, with its smooth muscle isoform. This study shows that along with the replacement of actin isoform the key structural sarcomeric proteins are released from actin structures and stored in cell cytoplasm as inclusions not bound with actin. The data obtained are indicative of the incompatibility of smooth muscle actin with sarcomeric isoforms of these proteins and myofibrillar organization in general.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5d58952e879c6a91fe0128960b79fba6 https://doi.org/10.1134/s1990519x1905002x Zobrazit plný text záznamu Full text from SpringerLink