Sirolimus in blue rubber bleb naevus syndrome: A systematic review
| Autor: | Xin Lin Wong, Deshan F. Sebaratnam, Kevin Phan, Ana Isabel Rodríguez Bandera |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
business.industry Vascular malformation MEDLINE equipment and supplies medicine.disease Dermatology 03 medical and health sciences surgical procedures operative 0302 clinical medicine Gastrointestinal disease 030225 pediatrics Sirolimus Pediatrics Perinatology and Child Health medicine 030212 general & internal medicine business Venous malformation Blue rubber bleb naevus syndrome medicine.drug |
| Zdroj: | Journal of Paediatrics and Child Health. 55:152-155 |
| ISSN: | 1034-4810 |
| Popis: | The aim of this study is to review sirolimus as a treatment for blue rubber bleb naevus syndrome (BRBNS). A literature search of Medline, Embase, CINAHL, SCOPUS and Google Scholar was conducted for publications reporting treatment of patients with BRBNS with sirolimus. Of 46 articles identified, 17 studies reporting 23 patients met inclusion criteria. Sirolimus was well tolerated in all but one patient who required treatment cessation; 17/18 patients noted an improvement in gastrointestinal disease where this was reported; 21/22 patients noted an improvement in cutaneous disease where this was reported. Based on these results, sirolimus may be considered a first-line treatment of BRBNS depending on patient morbidity. |
| Databáze: | OpenAIRE |
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