Insulin resistance after a 3-day fast is associated with an increased capacity of skeletal muscle to oxidize lipids

Autor:	Sarah J. Blackwood, Oscar Horwath, Marcus Moberg, Marjan Pontén, William Apró, Maria M. Ekblom, Filip J. Larsen, Abram Katz
Rok vydání:	2023
Předmět:	Physiology Physiology (medical) Endocrinology Diabetes and Metabolism
Zdroj:	American Journal of Physiology-Endocrinology and Metabolism. 324:E390-E401
ISSN:	1522-1555 0193-1849
DOI:	10.1152/ajpendo.00317.2022
Popis:	Whether lipid-mediated insulin resistance occurs as a result of an increased or decreased capacity of skeletal muscle to oxidize lipids has been debated. We show that a 3-day fast results in increases in circulating lipids and insulin resistance in subjects expressing a high or low proportion of type I muscle fibers. High expression of type I is associated with a higher capacity to oxidize lipids and a greater loss of insulin sensitivity after starvation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5d53590f8dc40b03f33e88352f534891 https://doi.org/10.1152/ajpendo.00317.2022 Zobrazit plný text záznamu