Self-accelerated electrochemiluminescence emitters of Ag@SnO2 nanoflowers for sensitive detection of cardiac troponin T
| Autor: | Ming-Hui Jiang, Yaqin Chai, Pei Lu, Ying Zhuo, Yan-Mei Lei, Ruo Yuan |
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| Rok vydání: | 2018 |
| Předmět: |
Detection limit
Nanostructure Materials science General Chemical Engineering chemistry.chemical_element Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Silver nanoparticle 0104 chemical sciences chemistry Nanocrystal Linear range Electrochemistry Electrochemiluminescence 0210 nano-technology Tin Biosensor |
| Zdroj: | Electrochimica Acta. 271:464-471 |
| ISSN: | 0013-4686 |
| DOI: | 10.1016/j.electacta.2018.03.177 |
| Popis: | Metal oxide semiconductor nanocrystals (NCs), which emerged as a novel class of electrochemiluminescence (ECL) emitters with low cost and good biocompatibility, have attracted particular research interests in ECL biosensors. However, their analytical applications still remained a substantial challenge of relatively low ECL intensity. Herein, the novel self-accelerated ECL emitters of silver nanoparticles functionalized SnO2 nanoflowers (Ag@SnO2 NFs) were first prepared by in situ generating silver nanoparticles on the surface of SnO2 nanoflowers via silver mirror reaction, which exhibited high-intensity ECL emission with the maximum emission peak at 542 nm in the case of S2O82− as a co-reactant. It was worthy to note that compared with traditional ECL emitters of SnO2 NCs with diameters below 10 nm, the obtained Ag@SnO2 NFs with diameters about 1–2 μM showed a stronger ECL emission. The ECL enhancement was supposed to derive from 1) the strong size effect of flower-like nanostructure aggregating by ultrathin SnO2 nanosheets, which would offer large amount of tin interstitials or oxygen vacancies; 2) the in situ generated silver nanoparticles (Ag NPs) as co-reaction accelerator, which would generate more oxidizing intermediate ( ) to significantly self-promote the ECL emission of Ag@SnO2 NFs. Given these attributes, we developed a sensitive ECL immunosensor for the detection of cardiac troponin T (cTnT) utilizing Ag@SnO2 NFs as efficient signal probes, which showed outstanding sensitivity with a favorable linear range from 1 fg/mL to 100 pg/mL and relatively low detection limit of 0.11 fg/mL. This work efficiently offered insights into the promising applications of Ag@SnO2 NFs as a low toxicity and superior ECL emitter in ECL bioanalysis. |
| Databáze: | OpenAIRE |
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