Study on the formulation of o/w emulsion as carriers for lipophilic drugs
| Autor: | Rou-Yen Kung, Zhi-Beng Chen, Pei Kan, Chau-Jen Lee, I-Ming Chu |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
food.ingredient
Aqueous solution Chromatography Surfaces and Interfaces General Medicine Soybean oil chemistry.chemical_compound Colloid and Surface Chemistry food chemistry Phosphatidylcholine Emulsion Drug delivery Glycerol Particle size Physical and Theoretical Chemistry Drug metabolism Biotechnology Nuclear chemistry |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 15:117-125 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/s0927-7765(99)00048-x |
| Popis: | Soybean oil, white mineral oil and tricaprylin were employed with various emulsifiers to create o/w (oil-in-water) emulsion with particle size ranging from 70 to 200 nm for potential drug delivery applications. Suitable formulation of this o/w emulsion was sought for, with aims of good shelf stability (in particle size and drug retention), and high drug loading capacity. Nonionic surfactants, including Cremophore EL, Pluronic F68 and Tween 80, were compared when used in combination with egg phosphatidylcholine (EPC) as the emulsifiers in this study. The effect of types of emulsifiers and oils used on the particle size and shelf stability was investigated. The results revealed a synergistic effect of surfactants EPC and Tween 80 on emulsion stability, with an optimum ratio of ca. 1:1 wt/wt. Emulsion made of the following formulation was found to posses small size around 80–120 nm and good storage stability: tircaprylin/Tween 80/EPC (1 g/0.3 g/0.4 g) in 40 ml of 2.25% glycerol aqueous solution. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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