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Introduction Laboratory abnormalities and obesity may be associated with perinatal outcomes in patients with pre-eclampsia. Analysis of these factors may guide damage prevention strategies. Objective To associate laboratory variables and maternal body mass index (BMI) with childbirth outcome before 34 and 37 weeks and perinatal outcomes in cases of pre-eclampsia. Methods Cohort study. Location: Guilherme Alvaro Hospital, Santos/Brazil; (May/2017–April/ 2018). Inclusion: women with pre-eclampsia (NHBPEP; 2000) and preterm delivery. Group 1: delivery 6 mg/dl), liver enzymes (AST> 34 U/I and ALT> 35 U/I), obesity (BMI> 30), neonatal ICU admission. Statistical analysis: Fisher’s exact test (significance p Results Sample size: 90 patients. Group 1: AST elevation in 53.3% of the pacients (p = 0.001); ALT elevation in 46.7% (p = 0.001), uric acid elevation in 28.6% (p = 0.068) and 12.5% were obese (p = 0.044). Group 2: AST elevation in 30.2% of the pacients (p = 0.001); ALT elevation in 23.3% (p = 0.004); uric acid elevation in 20% (p = 0.085) and 24.4% were obese (p = 0.047). Of the total sample, 45.6% of newborns were admitted to the neonatal ICU. Discussion In Group 1, with more severe prematurity, hepatic damage and elevated uricemia were more frequent. In Group 2, obesity was more prevalent, corroborating with the literature (Chaemsaithong P, 2018). The neonatal ICU admission of the total sample was significantly elevated. This behavior of the indirectly recognized target organ damage and lipotoxicity, associated with the severity of prematurity, may represent indicators regarding the higher expression of preeclampsia causing preterm delivery, the need to guide prophylaxis strategies and eventually prognostic counseling. Enlarging the sample may add information. |
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