| Autor: |
Yasuhiro Tani, Ryu Ishihara, Noriko Matsuura, Yuki Okubo, Yushi Kawakami, Hirohisa Sakurai, Takahiko Nakamura, Katsunori Matsueda, Muneaki Miyake, Satoki Shichijo, Akira Maekawa, Takashi Kanesaka, Sachiko Yamamoto, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Tomoki Michida |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-2196701/v1 |
| Popis: |
Background: Chemoradiotherapy (CRT) and radiotherapy (RT) are treatment options for esophageal squamous cell carcinoma (ESCC), but local residual/recurrent cancer after CRT/RT is a major problem. Endoscopic resection (ER) is an effective treatment option for local residual/recurrent cancer. To ensure the efficacy of ER, complete removal of endoscopically visible lesions with cancer-free vertical margins is desired. This study aimed to identify endoscopic parameters associated with the complete endoscopic removal of local residual/recurrent cancer. Methods: In this single-center, retrospective study, we used a prospectively maintained database to identify esophageal lesions that were diagnosed as local residual/recurrent cancer after CRT/RT and treated by ER between January 2012 and December 2019. We evaluated the associations of endoscopic R0 resection with findings on conventional endoscopy and endoscopic ultrasonography (EUS). Results: In total, 98 lesions (83 cases) were identified from our database. The rate of endoscopic R0 resection was higher for flat lesions (100% versus 77%, P = 0.00014). EUS was performed for 24 non-flat lesions, and endoscopic R0 resection was achieved for 94% of lesions with an uninterrupted fifth layer. Conclusions: Flat lesions on conventional endoscopy and lesions with an uninterrupted fifth layer on EUS are good candidates for ER. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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