ChemInform Abstract: Diastereoselective Addition of Higher Order Cuprates and Zinc-Copper Reagents to Imines Derived from (S)-1-Phenylethylamine

Autor:	Marzia Villa, Pier Giorgio Cozzi, Achille Umani‐Ronchi, Marco Bandini
Rok vydání:	2010
Předmět:	chemistry.chemical_compound 1-Phenylethylamine chemistry Reagent chemistry.chemical_element Cuprate General Medicine Zinc Medicinal chemistry Copper
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
Popis:	The diastereoselective addition of higher order (H.O.) cuprates and zinc-copper reagents to aliphatic and aromatic chiral imines derived from ( S )-1-phenylethylamine was examined. Aliphatic chiral imines react with (Allyl) 2 CuCNLi 2 and (n-Bu) 2 Cu(CN)Li 2 in the presence of BF 3 ·Et 2 O and Me 3 SiCl in high diastereoselection, while c-C 6 H 11 Cu(CN)ZnI and AllylCu(CN)ZnBr afford chiral amines in comparable yields without additives. Moreover the synthesis of a key intermediate towards a δ-amino-acid was reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5d45e7858b2d015086d889f1e849c489 https://doi.org/10.1002/chin.199940053 Zobrazit plný text záznamu Plný text