Muscle recovery after immobilisation by external fixation
| Autor: | Abraham Z. Reznick, Raymond Coleman, G. Volpin, D. Fuchs, Haim Stein, N. Zarzhevsky |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
biology business.industry medicine.medical_treatment Acid phosphatase Hindlimb Anatomy medicine.disease External fixation Gastrocnemius muscle Endocrinology Atrophy Internal medicine medicine biology.protein Orthopedics and Sports Medicine Surgery Histopathology Creatine kinase medicine.symptom Myopathy business |
| Zdroj: | The Journal of Bone and Joint Surgery. British volume. :896-901 |
| ISSN: | 2044-5377 0301-620X |
| Popis: | We immobilised the right hindlimbs of six-month-old female Wistar rats for four weeks using a biplanar external fixation bridging the knee. The untreated left limbs served as a control group. An additional group of rats was allowed to recover for four weeks after removal of the frame. Immobilisation caused reduction in the wet weights of approximately 50% in the gastrocnemius, quadriceps, soleus and plantaris muscles; this was not restored completely after remobilisation. There was an increase in the activity of acid phosphatase of approximately 85% in the gastrocnemius and quadriceps muscles whereas that of creatine phosphokinase was reduced by about 40%. These values returned to nearly normal after remobilisation. Histological and ultrastructural examination showed a marked myopathy of the gastrocnemius muscle after immobilisation although the morphology was largely restored after remobilisation. We conclude that after four weeks of remobilisation, hind-limb muscles do not return to preimmobilisation weights, although biochemical activities and ultrastructural appearance are largely restored. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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