Microbial Biofilm May Contribute to Alzheimer's Disease

Autor: Randall D. Wolcott
Rok vydání: 2020
Předmět:
Zdroj: Clinical Microbiology Newsletter. 42:181-186
ISSN: 0196-4399
Popis: This review describes what is currently known regarding the interplay of microbial biofilms and the chronic illness known as Alzheimer's disease. Additionally, a view into the future of clinical microbiology as it responds to assessment of biofilms is included. The biofilm subcommittee for the European Infectious Disease Society has utilized the molecular, microscopic, and clinical scientific findings to conclude that biofilms cause chronic infections. In their guidelines, the biofilm group implies that every human tissue is susceptible to chronic infection by microorganisms growing in the “biofilm phenotype.” Chronic inflammation is felt to be one of the most important contributing factors to amyloid diseases. Yet, the exact cause of the inflammation and its mechanisms for cell death and dysfunction remain elusive. The available literature defines the process of amyloid formation from seeding through the development of fibrils to the eventual steady state of the amyloid deposit. Despite the descriptive literature, a critical question remains: “What causes the initiation and perpetuation of the amyloid cascade?” Although the associations are evolving, neuroinflammation may play a role, as it has been recognized as a significant component of Alzheimer's disease pathology for several decades. Chronic inflammation is frequently observed in amyloid diseases and may be an important contributing factor to amyloidosis protein toxicity. It is widely accepted that this neuroinflammation drives the entire progression of Alzheimer disease.
Databáze: OpenAIRE
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