Pharmacokinetics
| Autor: | B.J. Gurley, R. Delgoda, S.C. Turfus, D. Picking |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Volume of distribution
Drug Chemistry media_common.quotation_subject Dosing regimen Computational biology 030226 pharmacology & pharmacy Bioavailability 03 medical and health sciences 0302 clinical medicine Pharmacokinetics 030220 oncology & carcinogenesis Detoxification Distribution (pharmacology) media_common |
| DOI: | 10.1016/b978-0-12-802104-0.00025-1 |
| Popis: | The pharmacokinetics of a compound is dependent upon its physicochemical properties, intrinsic clearance, and apparent volume of distribution, as well as its interaction with various tissue types. As well as determining safety and efficacy, pharmacokinetic studies serve as a means of describing comparisons between the disposition of formulations and can be used as the basis for tailoring the compound to another dosing regimen. The wide variety of structures of natural products result in a number of metabolic routes and detoxification mechanisms. The mathematical principles are presented graphically. Finally, drug interactions, particularly involving cytochrome P450 inhibition or enhancement, are discussed. |
| Databáze: | OpenAIRE |
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