Lack of β adrenoceptor desensitization in brain following the dual noradrenaline and serotonin reuptake inhibitor venlafaxine1The studies reported in this paper were conducted while Irena Nalepa was a Visiting Scientist from the Institute of Pharmacology of the Polish Academy of Sciences, Krakow, Poland.1
| Autor: | Fridolin Sulser, D. D. Gillespie, S. Paul Rossby, Irena Nalepa, Dennis E. Schmidt, D. Hal Manier |
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| Rok vydání: | 1998 |
| Předmět: |
Pharmacology
medicine.medical_specialty Chemistry Serotonin reuptake inhibitor Adenylate kinase Venlafaxine Serotonergic Cyclase Psychiatry and Mental health Endocrinology Neurology Internal medicine Second messenger system medicine Pharmacology (medical) Neurology (clinical) Serotonin Reuptake inhibitor Biological Psychiatry medicine.drug |
| Zdroj: | European Neuropsychopharmacology. 8:227-232 |
| ISSN: | 0924-977X |
| DOI: | 10.1016/s0924-977x(97)00078-3 |
| Popis: | Venlafaxine, a dual amine reuptake inhibitor, was utilized to delineate the role of the individual aminergic components of the `serotonin/noradrenaline link' in modifying receptor-linked second messenger cascades. Venlafaxine (20 mg/kg i.p. bid for 10 days) failed to alter in normal animals either the density of β adrenoceptors or the response of the β adrenoceptor-coupled adenylate cyclase system to noradrenaline but significantly decreased the cyclic AMP response to noradrenaline in the brain of rats with selective depletion of brain serotonin by p-chlorophenylalanine. The studies provide evidence for a cross-talk between noradrenergic and serotonergic receptor cascades at the level of mechanisms involved in the desensitization of the β adrenoceptor-coupled adenylate cyclase system. |
| Databáze: | OpenAIRE |
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