The effect of modifying an edge-plane pyrolytic graphite electrode with single-wall carbon nanotubes on its use for sensing diclofenac

Autor:	Anoop Raj Singh Rana, Rajendra N. Goyal, Sanghamitra Chatterjee
Rok vydání:	2010
Předmět:	Detection limit Materials science Calibration curve Analytical chemistry chemistry.chemical_element General Chemistry Carbon nanotube law.invention chemistry law Electrode General Materials Science Pyrolytic carbon Graphite Voltammetry Carbon
Zdroj:	Carbon. 48:4136-4144
ISSN:	0008-6223
DOI:	10.1016/j.carbon.2010.07.024
Popis:	A simple and highly sensitive sensor based on edge-plane pyrolytic graphite electrode (EPPGE) coated with single-wall carbon nanotubes is proposed for diclofenac determination in nanomolar concentrations. The oxidation of diclofenac occurred in two well-defined peaks having peak potentials ∼439 and ∼854 mV at pH 7.2. The modified electrode showed excellent catalytic activity presenting much higher peak currents than those measured on a bare EPPGE. Under the optimum conditions, the calibration curve was linear in the concentration range 1 × 10−9–500 × 10−9 M and 25 × 10−9–1500 × 10−9 M for peaks I and II, respectively. The limit of detection for peaks I and II was found as 0.82 × 10−9 and 22.5 × 10−9 M, respectively. The developed sensor was applied for the determination of diclofenac in biological and pharmaceutical samples using square-wave voltammetry and the validation of results using high performance liquid chromatography showed excellent agreement.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5d0d844af4c585f675251ff23ad9806d https://doi.org/10.1016/j.carbon.2010.07.024 Zobrazit plný text záznamu Full Text from ScienceDirect