| Autor: |
Wei Zhou, Yi Pan, Zhijin Lu, Chen Xie, Zhiqiang Duan, Jianlin Han |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Chinese Journal of Chemistry. 30:2333-2337 |
| ISSN: |
1001-604X |
| DOI: |
10.1002/cjoc.201200586 |
| Popis: |
The first direct asymmetric Mannich reaction of malononitrile to N-Boc-protected imines has been developed with cinchona alkaloid as catalyst. The procedure could tolerate a relatively wide range of substrates, and results in excellent yields and good enantioselectivities even in the presence of only 1 mol% of catalyst loading. The present work provides an easy access to β-amino malononitrile derivatives. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
