SP2.2.6 Long-term outcome predictors in laparoscopic minor hepatectomy for hepatocellular carcinoma in the UK
| Autor: | Crispin Schneider, Diana Bogatu, John Leahy, Priya Patel, Nigel Heaton, Krish Menon |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | British Journal of Surgery. 109 |
| ISSN: | 1365-2168 0007-1323 |
| Popis: | Aims Minor hepatectomy, which is increasingly carried out laparoscopically (LLR), is a cornerstone of curative treatment for hepatocellular carcinoma (HCC). The majority of relevant publications however originate from regions with endemic viral hepatitis. Although the incidence of HCC in the UK is increasing, little is known about outcomes following LLR. Methods Consecutive patients undergoing minor (involving ≤2 segments) LLR or open resection (OLR) at our institute between 2014–2021 were compared. Selection from a plethora of factors potentially impacting disease free survival (DFS) was optimised with Lasso regression. To enable analysis of patients having repeat resection, multivariate frailty modelling was utilised to calculate hazard ratios (HR). Results There were 111 liver resections with 55 and 56 patients undergoing LLR or OLR, respectively. LLR patients had a shorter hospital stay (5±2 vs. 7±2 days; p Conclusions In the studied population minor LLR was associated with shorter hospital stay and fewer complications while offering non-inferior long-term outcomes. Neoadjuvant and adjuvant therapy for HCC are increasingly being employed and it is hoped that the outcome predictors identified here, may aid in selecting patients who are most likely to benefit from these adjuncts. |
| Databáze: | OpenAIRE |
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