Induction of hepatic P450-dependent monooxygenase in feral mice from a PCDD/PCDF-contaminated area
| Autor: | Hermann Brunner, Karl Walter Bock, Thomas Wiesmüller, Dieter Schrenk, Hanspaul Hagenmaier, Hans-Peter Lipp |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Environmental Engineering
Chemistry Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health General Medicine General Chemistry Monooxygenase Contamination Pollution Soil contamination Pcdd pcdf Toxicology Environmental chemistry Ethoxyresorufin O-Deethylase Environmental Chemistry |
| Zdroj: | Chemosphere. 22:1011-1018 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/0045-6535(91)90302-t |
| Popis: | Increased PCDD/PCDF levels were detectable in liver of feral mice (Microtus arvalis) living in PCDD/PCDF contaminated areas (up to 27800 ng TE/kg soil) of a former cable pyrolysis plant, in comparison with animals from a control area. The pattern of PCDD/PCDF congeners showed marked differences between soil and liver. Hepatic 7-ethoxyresorufin O-deethylase (EROD; a functional parameter for PCDD/PCDF-inducible cytochrome P450IA1) was increased in feral mice in relation to the degree of soil contamination with PCDD/PCDF. The data suggest that hepatic EROD activity is a useful bioindicator of the exposure of wild mammalian populations with PCDD/PCDF. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|