Expression of β-dystroglycan is reduced or absent in many human carcinomas
| Autor: | Sabapathy P. Balasubramanian, MW Reed, F.C. Hamdy, James W.F. Catto, C L Eaton, A Mitchell, Steve J. Winder, Simon S. Cross, J M Lippitt, F Hollingsbury |
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| Rok vydání: | 2008 |
| Předmět: |
musculoskeletal diseases
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Pathology animal structures Histology Tissue microarray biology Cell Cancer Anatomical pathology General Medicine musculoskeletal system medicine.disease Pathology and Forensic Medicine medicine.anatomical_structure Dystroglycan biology.protein medicine Carcinoma Immunohistochemistry Urothelium tissues |
| Zdroj: | Histopathology. 53:561-566 |
| ISSN: | 0309-0167 |
| Popis: | AIMS Dystroglycan is an important structural and signalling protein that is expressed in most human cells. alpha-Dystroglycan has been investigated and found to be reduced in human cancers, but there is only one published study on the expression of beta-dystroglycan in human cancer and that was only on small numbers of breast and prostatic cancers. The aim was to conduct a comprehensive immunohistochemical survey of the expression of beta-dystroglycan in normal human tissues and common cancers. METHODS AND RESULTS Triplicate tissue microarrays of 681 samples of normal human tissues and common cancers were stained using an antibody directed against the cytoplasmic component of beta-dystroglycan. beta-Dystroglycan was strongly expressed at the intercellular junctions and basement membranes of all normal human epithelia. Expression of beta-dystroglycan was absent or markedly reduced in 100% of oesophageal adenocarcinomas, 97% of colonic cancers, 100% of transitional cell carcinomas of the urothelium and 94% of breast cancers. In the breast cancers, the only tumours that showed any retention of beta-dystroglycan expression were small low-grade oestrogen receptor-positive tumours. The only cancers that showed retention of beta-dystroglycan expression were cutaneous basal cell carcinomas. CONCLUSIONS There is loss or marked reduction of beta-dystroglycan expression (by immunohistochemistry) in the vast majority of human cancers surveyed. Since beta-dystroglycan is postulated to have a tumour suppressor effect, this loss may have important functional significance. |
| Databáze: | OpenAIRE |
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