Effect of different immunization and challenge procedures on in vivo tumor immunogenicity tests
| Autor: | Ellen M. Lawler, Henry C. Outzen, Richmond T. Prehn |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Cancer Research
business.industry animal diseases Immunogenicity Immunology Antitumor response chemical and pharmacologic phenomena biochemical phenomena metabolism and nutrition medicine.disease Tumor tissue chemistry.chemical_compound Oncology chemistry Immunization In vivo Immunity Methylcholanthrene medicine bacteria Immunology and Allergy Sarcoma business |
| Zdroj: | Cancer Immunology Immunotherapy. 11 |
| ISSN: | 1432-0851 0340-7004 |
| DOI: | 10.1007/bf00205780 |
| Popis: | Three different methods of immunization and two methods of challenge were used to test a series of methylcholanthrene (MCA)-induced sarcomas for their immunogenicities in vivo. Although there was some variation in the degree of immunity produced, similar results were obtained with the three immunization procedures. Challenge with explants of tumor tissue was found to be as sensitive a measurement of the antitumor response as challenge with a single cell suspension. The results indicate that in a substantial series of tumors, the relative immunogenicities are characteristics of the tumors themselves and not artifacts due to the immunization or challenge procedures used. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink