Mast cell-macrophage interactions alter inflammatory cytokine production. (177.10)
| Autor: | Tenchee Lama Tamang, Nicholas Pullen, John Ryan |
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| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 188:177.10-177.10 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Increased levels of mast cells and macrophages are seen at the tumor microenvironment. Mast cells are associated with tumor progression, and macrophages have been observed to induce cancer cell motility and angiogenesis. Like mast cells, macrophages produce inflammatory cytokines such as TNF, IL-13, IL-6 and MIP-1α. The individual role of these cells are well-recognized, but very little is known about their potential interactions in this microenvironment. Our preliminary studies demonstrate that co-culturing mast cells with macrophages elevates inflammatory cytokine production. Cultures of IgE-sensitized, antigen stimulated mast cells mixed with macrophages produced higher concentration of inflammatory cytokines than either cell population alone. These data demonstrate the possibility that communication between mast cells and macrophages may alter one another’s functions, especially cytokine secretion. These studies will help us gain a better understanding of the role of mast cell-macrophage interactions and how they may contribute to both normal and pathological immunity. |
| Databáze: | OpenAIRE |
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