Skin reaction to adalimumab
| Autor: | J. von Kempis, W. Beuthien, H.-U. Mellinghoff |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Erythema business.industry Immunology Arthritis medicine.disease Dermatology Rheumatology Infliximab Etanercept Rheumatoid arthritis Internal medicine medicine Adalimumab Immunology and Allergy Pharmacology (medical) medicine.symptom skin and connective tissue diseases business medicine.drug Leflunomide |
| Zdroj: | Arthritis & Rheumatism. 50:1690-1692 |
| ISSN: | 1529-0131 0004-3591 |
| DOI: | 10.1002/art.20155 |
| Popis: | The tumor necrosis factor alpha (TNFalpha) inhibitors etanercept and infliximab have shown good clinical results in the treatment of rheumatoid arthritis and other autoimmune disorders. With these novel fusion proteins, immune-mediated side effects, among them various cutaneous reactions, have been encountered. We report herein the case of an erythema multiforme-like skin reaction to treatment with the monoclonal anti-TNFalpha antibody adalimumab in a patient with rheumatoid arthritis. The reaction occurred after the sixth injection and affected the palms and soles as well as the injection site. Discontinuation of the adalimumab therapy resulted in rapid improvement of the condition. Although this patient was receiving concomitant immunomodulatory therapy with methotrexate and leflunomide, these medications were not discontinued when the reaction developed, and no other potential pathogenetic mechanisms were identified. We believe the reaction is most likely attributable to adalimumab. |
| Databáze: | OpenAIRE |
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