252-OR: Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02
| Autor: | KIMBER SIMMONS, ANGELA M. MITCHELL, AIMON ALKANANI, KRISTEN MCDANIEL, ERIN BASCHAL, TAYLOR ARMSTRONG, LAURA PYLE, LIPING YU, AARON W. MICHELS |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Diabetes. 69 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/db20-252-or |
| Popis: | Human leucocyte antigen (HLA) class II genes confer significant genetic risk for type 1 diabetes (T1D) development and protection. The dominant protection afforded by the DRB1*15:01 (DR15)-DQA1*01:02-DQB1*06:02 (DQ6) haplotype across all stages of T1D is well documented. This is a common haplotype found in Caucasians but present in In conclusion, studying the clinical, immunologic and genetic features of individuals that failed genetic protection holds promise for understanding mechanisms that ultimately lead to beta cell destruction in T1D. Disclosure K. Simmons: None. A.M. Mitchell: None. A. Alkanani: None. K. McDaniel: None. E. Baschal: None. T. Armstrong: None. L. Pyle: None. L. Yu: None. A.W. Michels: Other Relationship; Self; ImmunoMolecular Therapeutics, LLC. Funding National Institutes of Health (DK095995, DK108868, DK110845, DK032083, K12DK094712-08); JDRF/Children’s Diabetes Foundation (2-SRA-2016-202-5-B); Colorado Clinical and Translational Science Institute (TR001082) |
| Databáze: | OpenAIRE |
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