Reactivity of lymphoid cells in stressed mice against the background of adrenoceptor blockade
| Autor: | E. Yu. Sherstoboev, O. S. Borsuk, A. P. Babenko, N. V. Masnaya |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment General Medicine Propranolol Dihydroergotamine General Biochemistry Genetics and Molecular Biology Endocrinology Cytokine Immune system Immunization Internal medicine medicine Adrenoceptor blockade Tumor necrosis factor alpha business medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 143:9-13 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-007-0070-6 |
| Popis: | Injection of α-adrenoblocker dihydroergotamine to (CBA×C57Bl/6)F1 mice against the background of stress and subsequent immunization considerably suppressed production of Th1 (IFN-γ and IL-2) and Th2 (IL-10) cytokines and IL-6 and stimulated TNF-α production. Injection of β-adrenoceptor blocker propranolol in stressed and immunized mice shifted the cytokine balance towards Th1 by stimulating IFN-γ and IL-2 production and inhibiting IL-10 production at early stages of humoral immune response; the production of TNF-α and IL-6 increased under these conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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