Trudności diagnostyczne u dziewczynki z wieloukładową histiocytozą z komórek Langerhansa – opis przypadku
| Autor: | Elżbieta Adamkiewicz-Drożyńska, Lucyna Maciejka-Kemblowska, Malgorzata Krawczyk, Ewa Iżycka-Świeszewska, Marek Tomaszewski, Gabrielle Karpinsky, Ninela Irga-Jaworska, Ewa Bien, Anna Lemska |
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| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test Anemia business.industry Hepatosplenomegaly medicine.disease medicine.anatomical_structure Bone scintigraphy Langerhans cell histiocytosis Pediatrics Perinatology and Child Health medicine Etiology Bone marrow medicine.symptom business Lymph node Rare disease |
| Zdroj: | Pediatria Polska. 90:76-80 |
| ISSN: | 0031-3939 |
| Popis: | Langerhans cell histiocytosis (LCH) is a rare disease of unknown etiology and varied picture and clinical course. The intensity and the outcome of LCH treatment depend on the amount and type of the affected organs, their dysfunction and age of the patient. In this paper we present the diagnostic difficulties in a 19-month-old girl with multisystem LCH, manifesting mainly by persistent fever, deep anemia, hepatosplenomegaly and lymphadenopathy, coexisting with EBV infection and urinary tract infection. On diagnosis, LCH was suspected once the bone lesions were detected on CT scans, which, however, were not confirmed in the bone scintigraphy. Histopathological diagnosis of LCH was based on the histopathological examination of the cervical lymph node, in which CD1a expression was detected. Myelogram morphologically was assessed as normal; however, bone marrow smears were respectively found to express CD1a. The patient received aggressive and long-lasting treatment according to the protocol LCH in 2009, yielding a complete clinical remission of LCH. |
| Databáze: | OpenAIRE |
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