ChemInform Abstract: An Inexpensive and Recyclable Silver-Foil Catalyst for the Cyclopropanation of Alkenes with Diazoacetates under Mechanochemical Conditions

Autor:	Mark O. Bovee, Kimberlee Keithley, Michael G. Coleman, Longrui Chen, Betsegaw E. Lemma, Sara L. Pilson, James Mack
Rok vydání:	2016
Předmět:	Metal Chemistry Cyclopropanation visual_art Polymer chemistry visual_art.visual_art_medium Reactivity (chemistry) General Medicine Inert gas Selectivity FOIL method Catalysis
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201605085
Popis:	The diastereoselective cyclopropanation of various alkenes with diazoacetate derivatives can be achieved under mechanochemical conditions using metallic silver foil and a stainless-steel vial and ball system. This solvent-free method displays analogous reactivity and selectivity to solution-phase reactions without the need for slow diazoacetate addition or an inert atmosphere. The heterogeneous silver-foil catalyst system is easily recyclable without any appreciable loss of activity or selectivity being observed. The cyclopropanation products were obtained with excellent diastereoselectivities (up to 98:2 d.r.) and in high yields (up to 96 %).
Databáze:	OpenAIRE
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