Coordination compounds in medicinal chemistry

Autor:	Chad W. Schwietert, John P. McCue
Rok vydání:	1999
Předmět:	Inorganic Chemistry chemistry.chemical_classification Chemistry Materials Chemistry Anti infectives Organic chemistry Tumor growth Physical and Theoretical Chemistry Medicinal chemistry Coordination complex
Zdroj:	Coordination Chemistry Reviews. 184:67-89
ISSN:	0010-8545
DOI:	10.1016/s0010-8545(98)00205-7
Popis:	In medicinal chemistry metal complexes as pharmaceuticals have received limited attention compared with organic compounds. Much of the attention has been given to Pt(II) complexes that inhibit tumor growth, but a widely applicable target for development of metal complexes as pharmaceuticals has emerged from new perspectives of enzymes in disease processes. In this review we look at work involving the development of Fe(II), Pt(II), and Ti(IV) complexes as pharmaceuticals, and what this work reveals about transport of metal compounds across cell membranes and future roles for metallo-drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5cbefec3fa37c2d27f4015b8c45ce966 https://doi.org/10.1016/s0010-8545(98)00205-7 Zobrazit plný text záznamu Full Text from ScienceDirect