Prevention of early rejection of neural xenotransplants in the rat brain by the influence of magnetic field

Autor: E. V. Loseva, I. V. Ermakova, Yu. A. Kholodov
Rok vydání: 1997
Předmět:
Zdroj: Neurophysiology. 29:313-319
ISSN: 1573-9007
0090-2977
DOI: 10.1007/bf02463350
Popis: The effect of alternating low-frequency (50 Hz, 40 mT) magnetic field (MF) on preventing of early rejection of xenotransplants (XT) of the chicken embryo forebrain, grafted in the brain parenchyma of adults rats, was studied. For this purpose, rats with XT were treated with 1-h-long MF applications over 1, 3, and 5 days following neurotransplantation. The animals with XT, but without treatment with MF, were used as a control. Morphological analysis of XT and neighboring brain tissues of recipients was performed 5 days after transplantation. It was found that the action of MF prevented or substantially weakened reactions of XT rejection at early stages after XT grafting in the brain of recipient rats. Destruction of the neighboring brain tissues was decelerated, while in the control group of animals destructions were clearly manifested. Positive effect of MF was observed even after single 1-h-long application of MF the next day after the operation, and it did not change when MF treatment was repeated 3 or 5 times during the following days. It is suggested that MF depresses some cellular reactions, in particular migration of lymphocytes and reactive gliosis, which cause early XT rejection. A possibility that the MF effect is due to activation of immunodepressant factor and/or to blockade of antigen receptors of the main histocompatibility complex on the donor and/or recipient cell surface cannot be ruled out.
Databáze: OpenAIRE
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