γδ T cell-induced nitric oxide production enhances resistance to mucosal candidiasis

Autor:	Andrés Vázquez-Torres, Edward Balish, H C van der Heyde, R D Wagner, Jessica Jones-Carson, Thomas F. Warner
Rok vydání:	1995
Předmět:	biology T cell General Medicine biology.organism_classification General Biochemistry Genetics and Molecular Biology Microbiology Interleukin 21 Immune system medicine.anatomical_structure Antigen Interleukin 12 medicine Macrophage Gamma delta T cell Candida albicans
Zdroj:	Nature Medicine. 1:552-557
ISSN:	1546-170X 1078-8956
DOI:	10.1038/nm0695-552
Popis:	Despite the prevalence of gamma delta T cells in mucosae that are typically colonized by Candida albicans, little is known of the possible role of these cells in resistance to candidiasis. A sharp increase in the number of gamma delta T cells and macrophages following intraperitoneal inoculation of mice with C. albicans led us to examine the role of these cells in the immune response to C. albicans. We show that the gamma delta T cells enhance macrophage nitric oxide (NO) production and anti-candida activity, in vitro. We also propose that the gamma delta T cells regulate macrophage function during candidiasis in vivo as well, because depletion of these cells abrogated inducible NO synthase expression in mucosae and enhanced murine susceptibility to candidiasis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5cbc7c48473810edd12987e711b41de4 https://doi.org/10.1038/nm0695-552 Zobrazit plný text záznamu