Effects of Unripe Rubus coreanus Miquel Extract on Improvement of Lipid Metabolism in C57BL/6 Mice Fed a High-Cholesterol Diet
| Autor: | Myung-A Jung, Sook-Hyun Cho, Sun Young Lee, Ji Hye Kim, Kyonyeo Oh, Young-Suk Kim, GooSang Yoo, Dong-Wook Lee, Sunoh Kim |
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| Rok vydání: | 2014 |
| Předmět: |
Nutrition and Dietetics
biology Triglyceride Chemistry Cholesterol Rubus coreanus Lipid metabolism biology.organism_classification medicine.disease High cholesterol medicine.drug_formulation_ingredient chemistry.chemical_compound Biochemistry Functional food Oral administration medicine Borage seed oil lipids (amino acids peptides and proteins) Food science Food Science |
| Zdroj: | Journal of the Korean Society of Food Science and Nutrition. 43:650-655 |
| ISSN: | 1226-3311 |
| DOI: | 10.3746/jkfn.2014.43.5.650 |
| Popis: | † Jeonnam Bioindustry Foundation, Institute of Natural Resources Research (JINR), Jeonnam 529-851, Korea ABSTRACT Hypercholesterolemia is the presence of high levels of cholesterol in the blood, and it is regarded as a risk factor for cardiovascular disease due to the effects of cholesterol. The objective of this study was to investigate the effects of unripe Rubus coreanus Miquel (uRC) extract on lipid metabolism in hypercholesterolemic mice fed a high cholesterol diet (HC). uRC 50 (unripe R. coreanus 5% ethanol extract 50 mg/kg/day), uRC 100 (unripe R. coreanus 5% ethanol extract 100 mg/kg/day), uRC 300 (unripe R. coreanus 5% ethanol extract 300 mg/kg/day), and BO (borage seed oil containing minimum of 20% γ-linolenic acid 30 mg/kg/day) were orally administered for 60 days after HC. Oral administration of uRC 50, uRC 100, uRC 300, and BO significantly reduced serum total-cholesterol, triglyceride, LDL-cholesterol, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, atherogenic index, and cardiac risk factor levels. Similarly, uRC treatment elevated serum HDL-cholesterol levels. These results suggest that unripe R. coreanus extract could be established as a functional food for the improvement of lipid metabolism. |
| Databáze: | OpenAIRE |
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