Local Recurrence of Secondary Hemangiosarcoma Following Breast Radiation Therapy: A Case Report

Autor:	Hyunki Kim, Hee Jung Woo, Joon Jeong, Ah Young Park, Ji Hyun Youk, Jeong A Kim, Eun Ju Son
Rok vydání:	2010
Předmět:	medicine.medical_specialty business.industry medicine.medical_treatment Micrometastasis Context (language use) Sentinel node medicine.disease Surgery Radiation therapy Regimen Axilla Hemangiosarcoma Breast cancer medicine.anatomical_structure medicine Radiology Nuclear Medicine and imaging business
Zdroj:	Journal of the Korean Society of Radiology. 63:565
ISSN:	2288-2928 1738-2637
DOI:	10.3348/jksr.2010.63.6.565
Popis:	Secondary breast hemangiosarcomas are a very raremalignancy and usually divided into two subtypes: lym-phedema-associated cutaneous hemangiosarcomas andpostirradiation hemangiosarcomas (PIHs) (1, 2). PIHsare usually found in older women, who performedbreast-conserving therapy and radiation therapy, sever-al years after radiation therapy (1). According to previ-ous reports, PIHs show a low incidence of 0.05-1.11%(2). However, the increasing use of breast-conservingtherapy will predictably lead to an increased number ofPIHs (3). In addition, the rate of local recurrence of PIHsis as high as 73%, and the five-year-survival rate is only10-35% (4). Therefore, a high index of suspicion and anunderstanding of the imaging characteristics about thisdisease entity are necessary when dealing with patientswith PIHs. Here we present mammographic and sono-graphic findings of a case of locally recurred secondaryhemangiosarcoma in the context of prior breast-conser-vation therapy and radiation. Case ReportIn January 2001, a 50-year-old woman underwentbreast-conserving surgery with sentinel node biopsy ofthe ipsilateral axilla for a breast cancer in her rightbreast at our institution. The histologic report showed a1.6 cm, well-differentiated infiltrating ductal carcinoma.The resection margins were free of tumor, but onelymph node had micrometastasis of less than 2 mm. Thefinal TNM classification was T1N0M0. The patient un-derwent adjuvant external radiation therapy in the rightbreast with of 50.4 Gy plus a 9 Gy, as a boosting dose,for a total of 59.40 Gy over 50 days and five cycles of ad-juvant chemotherapy with a cyclophosphamide anddoxorubicin regimen. An annual follow-up mammogra-phy and biannual sonography revealed postoperative orradiation therapy-induced changes with no suspicious
Databáze:	OpenAIRE
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