New thiazolidinedione-5-acetic acid amide derivatives: synthesis, characterization and investigation of antimicrobial and cytotoxic properties

Autor:	Kallanagouda R. Alagawadi, Shankar G. Alegaon
Rok vydání:	2011
Předmět:	Serial dilution biology Stereochemistry Organic Chemistry Carbon-13 NMR Antimicrobial biology.organism_classification HeLa chemistry.chemical_compound Acetic acid chemistry Amide Cytotoxic T cell General Pharmacology Toxicology and Pharmaceutics Antibacterial activity Nuclear chemistry
Zdroj:	Medicinal Chemistry Research. 21:816-824
ISSN:	1554-8120 1054-2523
DOI:	10.1007/s00044-011-9598-0
Popis:	The present work describes the synthesis, antimicrobial and cytotoxic activity of 2,4-thiazolidinedione-5-acetic acid amides 3a–n. The structures of the compounds were confirmed by IR, 1H, 13C NMR and elemental analysis. All compounds were tested for antimicrobial activity by twofold serial dilution technique. The preliminary results revealed that the compound 3d exhibits promising antibacterial and antifungal activity. The cytotoxic (MTT) activity of 2,4-thiazolidinedione-5-acetic acid amides were tested in four tumour cell lines. We found that compound 3j inhibited proliferation of HeLa, HT29, A549 and MCF-7 cell lines with IC50 values of 33, 35, 30 and 36 μM, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5caeb01064ac31208b0d673bf24a1bf7 https://doi.org/10.1007/s00044-011-9598-0 Zobrazit plný text záznamu Full text from SpringerLink