Blennolide derivatives from the soil-derived fungus Trichoderma asperellum PSU-PSF14
| Autor: | Souwalak Phongpaichit, Sita Preedanon, Saowanit Saithong, Athip Maha, Patima Phainuphong, Jariya Sakayaroj, Vatcharin Rukachaisirikul, Siriporn Jungsuttiwong, Sarinya Hadsadee |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Cryptococcus neoformans
Antifungal biology 010405 organic chemistry medicine.drug_class Chemistry Stereochemistry Organic Chemistry Fungus biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Trichoderma asperellum 010404 medicinal & biomolecular chemistry Mic values Drug Discovery Vero cell medicine |
| Zdroj: | Tetrahedron. 74:5659-5664 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2018.07.041 |
| Popis: | Three new blennolide derivatives, blennolides L-N (1–3), together with five known metabolites were isolated from the soil-derived fungus Trichoderma asperellum PSU-PSF14. Their structures were determined by analysis of spectroscopic data. Their relative configurations were determined by analysis of NOEDIFF data and confirmed by X-ray crystallography for compound 1 whereas the absolute configurations were established by means of experimental and calculated TDDFT ECD data. Compound 1 displayed antifungal activity against Cryptococcus neoformans ATCC90112 and ATCC90113 flucytosine-resistant with the MIC values of 128 and 64 μg/mL, respectively, and was inactive against noncancerous Vero cell lines. |
| Databáze: | OpenAIRE |
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